By Pierre Hainaut, Klas G. Wiman
P53 has emerged as a key tumor suppressor and demanding objective for novel melanoma treatment. This booklet, written by way of world-leading p53 researchers together with lots of those that have formed the sector during the last 25 years, offers particular insights into the growth of the sector and the clients for larger melanoma prognosis and remedy sooner or later.
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Extra info for 25 Years of P53 Research
Emerson B. M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell 2001; 8:57-69. Espinosa J. , Verdun R. , Emerson B. M.
Poyurovsky is thanked for help in preparing this review. CP is supported by grants from the National Cancer Institute. , LoSardo J. , Gubler M. , Neri A. Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. Cancer Res 1995; 55:3490-4. , LoSardo J. , Gubler M. , Lu Y. , Neri A. Restoration of the transcription activation function to mutant p53 in human cancer cells. Oncogene 1996; 13:2477-82. , Prives C.
J Biol Chem 1999; 274:15237-44. Bullock A. , Fersht A. R. Rescuing the function f of mutant p53. Nat Rev Cancer 2001; 1:6876. , Laiho M. Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277. Nucleic Acids Res 2002; 30:2340-8. Bykov V. , Wiman K. , Selivanova G. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 2002; 8:282-8. , Prives C. The N terminus of p53 regulates its dissociation from DNA.
25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman