Download e-book for kindle: A Structural Perspective on Respiratory Complex I: Structure by Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov

By Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov (eds.)

ISBN-10: 9400741375

ISBN-13: 9789400741379

ISBN-10: 9400741383

ISBN-13: 9789400741386

The publication includes chapters written by way of leaders within the learn at the constitution and serve as of respiration advanced I. it's going to supply a concise and authoritative precis of the present wisdom on advanced I of breathing chains. This enzyme is vital to power metabolism and is implicated in lots of human neurodegenerative ailments, in addition to in getting older. till lately it used to be poorly understood on a structural point, and this publication will offer a well timed reference source. one of these e-book used to be now not released formerly. The final time a minireview sequence on advanced I have been released used to be in 2001, and because then complicated I box replaced fairly dramatically.

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Additional resources for A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase

Sample text

The late acquisition of NuoG and the separate and subsequent acquisition of NuoEF might be reflected in the different chromosomal localization of nuoG and nuoEF in A. aeolicus (Kohlstädt et al. 2008). The inability of N7 to participate in the physiological electron transfer reaction was shown by EPR spectroscopy (Pohl et al. 2007b). The EPR difference spectrum of complex I reduced either by NADH or by dithionite revealed the signals of a tetranuclear Fe/S cluster, which were attributed to N7. 047 (Fig.

1 V (Ingledew and Ohnishi 1980). 28 T. Friedrich et al. N2 is expected to be the direct reductant for the substrate (ubi)quinone. Two semiquinone species called QNf and QNs have been detected as essential intermediates during the turnover in the bovine heart complex I by means of EPR spectroscopy (Yano et al. 2000, 2005). The term ‘QN’ indicates their origin as semiquinones bound to complex I, while the subscript ‘f(ast)’ and ‘s(low)’ reflect their relaxation properties in EPR spectroscopy. The QNf signal is only detectable in the presence of a membrane potential.

2000). The latter complex was shown to react with flavodoxin rather than NADH (Weerakoon and Olson 2008). NuoE, F and G together with subunits NuoB, CD and I represent the seven globular proteins comprising the peripheral arm of the complex. The residual seven, most hydrophobic subunits NuoA, H, J, K, L, M and N build up the membrane arm. They include the ATS NuoL, M and N, which are derived from gene triplication (Kikuno and Miyata 1985; Fearnley and Walker 1992). 26 T. Friedrich et al. 1 Nomenclature, properties, and proposed functions of subunits of complex I Subunit E.

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A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase by Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov (eds.)


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