By George F. Vande Woude; George Klein (Eds.)
Advances in melanoma study presents helpful info at the intriguing and fast-moving box of melanoma research. In this half A volume, outstanding and unique stories supply an summary and synthesis of the newest options and findings in terms of Clusterin. Chapters contain the shifiting stability among CLU kinds in the course of tumor development, uclear CLU and the destiny of the mobile, and Oxidative tension in malignant development.
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Immunoassay suggestions became crucial in quite a few fields of natural and utilized examine. This quantity of the well-known Laboratory thoughts sequence could be of suggestions to those that have plans or are making efforts to boost ultrasensitive enzyme immunoassays for antigens and antibodies. the amount describes elements proscribing the sensitivity of noncompetitive strong section enzyme immunoassays, how you can triumph over problems restricting sensitivities, how to practice ultrasensitive enzyme immunoassays as speedily as attainable, and protocols of enzyme labeling and enzyme assays in addition to ultrasensitive enzyme immunoassays.
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2001). Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes. Exp. Cell Res. 271, 130–141. , et al. (1989). Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis. Biochem. J. 257, 293–296. , et al. (1999). Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts. FEBS Lett. 448, 297–300. Birkenmeier, E. , et al. (1993).
Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off-folding pathway. FEBS Lett. 513, 259–266. , et al. (2004). Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 23, 2298–2304. , et al. (2009). Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J. Cell. Physiol. 219, 314–323. , and Chen, C. L. (1994). Regulators for the rat clusterin gene: DNA methylation and cis-acting regulatory elements.
Physiol. 219, 314–323. , and Chen, C. L. (1994). Regulators for the rat clusterin gene: DNA methylation and cis-acting regulatory elements. J. Mol. Endocrinol. 13, 69–76. Rosenberg, M. , and Silkensen, J. (1995). Clusterin: Physiologic and pathophysiologic considerations. Int. J. Biochem. Cell Biol. 27, 633–645. , et al. (2004a). Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer. Int. J. Cancer 108, 23–30. , et al. (2004b). Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1.
Advances in Cancer Research by George F. Vande Woude; George Klein (Eds.)