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By Edited by Brahim Attaf

ISBN-10: 9533072350

ISBN-13: 9789533072357

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17) show relevant difference between the samples obtained in the presence and respectively in the absence of electric field. If different types of electric field are applied, different degrees of orientation are achieved. Fig. 17a, d show the microstructure of collagen/hydroxyapatite composite material obtained without electric field, Fig. 17b, e show the microstructure of collagen/ hydroxyapatite composite material, obtained by orientation in a pulsatory electric field and Fig. 17c, f show the microstructure of the composite material obtained in a combined (superposed) electric field.

Structural proteins such as fibrin have also been used in tissue engineering applications. Fibrin can be used as a natural wound healing material, and is most commonly used clinically as a sealant or adhesive. , 2008). , 2004) in vitro. , 2006). , 1994) and have been used as suture materials for over 20 years (Vepari and Kaplan, 2007). , 2003). e. skin, bone, and blood vessels and are a form of proteoglycan; organic polymers that are found in cells and that are a major component of the natural ECM.

Localised lowering of pH within the region of degradation can result in inflammatory responses. While these materials showed some promise, it is clearly evident from the lack of synthetic polymer-based products currently in use clinically as bone graft substitutes that synthetic polymers alone simply do not provide a sufficient degree of longterm biocompatibility or performance required for the clinically-successful regeneration of bone tissue. Composite Scaffolds for Orthopaedic Regenerative Medicine 39 Fig.

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Advances in Composite Materials for Medicine and Nanotechnology by Edited by Brahim Attaf

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