Advances in Immunology, Vol. 97 by Frederick W. Alt PDF

By Frederick W. Alt

ISBN-10: 0123743249

ISBN-13: 9780123743244

Advances in Immunology, a normal and hugely revered e-book, offers present advancements in addition to entire experiences in immunology. Articles handle the big variety of themes that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by means of the most important scientists within the box, every one quantity presents updated info and instructions for destiny study.

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Extra info for Advances in Immunology, Vol. 97

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This suggests that while ROCK is likely required for uropod maintenance through effects on myosin, it is not responsible for ERM-mediated cytoskeletal anchoring of cellular receptors. , 2003). , 2002). , 2007). , 2002). In addition, other emerging cytoskeletal regulatory effectors are likely to regulate chemotaxis. , 2006), have not yet focused on T cell 48 Timothy S. Gomez and Daniel D. Billadeau chemotaxis. However, recent studies of other leukocyte subsets indicate a role for this complex in migration.

2006). , 2001), suggesting that dock2À/À does not completely abolish migration. , 2004). While pi3kgÀ/À T cells showed a large defect in chemokine-mediated PKB phosphorylation, they displayed only slightly reduced migration to SLOs (15–30%). , 2004). Thus, it seems that T cell chemotaxis might occur via two distinct pathways, a major DOCK2-dependent and PI3K-independent pathway and a minor mechanism that is PI3K-dependent. , 2002). Thus, leukocyte subsets, or even T lymphocyte subsets, clearly rely on divergent mechanisms for setting up polarity and directed migration.

Chemokine signaling to F-actin remodeling and cell motility The pathways required for converting chemotactic signals into complex cytoskeletal changes during T cell migration have begun to emerge. Critically important are the chemoattractant cytokines, or chemokines (such as CXCL12, also known as stromal cell-derived factor 1a, SDF1a), which specifically interact with 7 transmembrane-spanning heterotrimeric G-protein-coupled receptors (GPCRs) (such as CXCR4, the receptor for SDF1a). Chemokines transmit signals leading to integrin activation, polarization, and F-actin remodeling, which coordinately regulate lymphocyte chemotaxis.

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Advances in Immunology, Vol. 97 by Frederick W. Alt

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